| OPT | Other People's Time |
| MINTEK | Council for Mineral Technology |
| IMR | Information Management Research |
| MERG | Macroeconomic Research Group |
| MIS | Management Information Systems |
| MIS | management information systems |
| MSRP | Manufacturer's Suggested Retail Price |
| MRP II | manufacturing resource planning |
| MERSETA | Manufacturing, Engineering and Related Services Education and Training Authority |
| MBA | Master's of Business Administration |
| MRP | material requirements planning |
| MAPPP | Media, Advertising, Printing, Publishing and Packaging SETA |
| MRC | Medical Research Council |
| MEDUNSA | Medical University Of Southern Africa |
| MTBPS | Medium Term Budget Policy Statement |
| MTEF | Medium-term expenditure framework |
| Mbps | Megabit Per Second |
| MBps | Megabyte Per Second |
| MSEs | Micro and very small enterprises |
| MCSE | Microsoft Certified Software Engineer |
| MSN | Microsoft Network |
| MCI | Microwave Communications Incorporated |
| Modem | MODulator-DEModulator |
| MLA | Monitoring Learning Achievement |
| MIDP | Motor Industry Development Programme |
| MP | Mpumalanga Province |
| MSI | Multiple Streams of Income |
| NACI | National Advisory Council on Innovation |
| NBI | National Business Initiative |
| NCHE | National Commission on Higher Education |
| NDoH | National Department of Health |
| NMC | National Manpower Commission |
| NPHE | National Plan for Higher Education |
| NQF | National Qualifications Framework |
| NRF | National Research Foundation |
| NSA | National Skills Authority |
| NSDS | National Skills Development Strategy |
| NSF | National Skills Fund |
| NSB | National Standards Bodies |
| NSFAS | National Student Financial Aid Scheme |
| NTB | National Training Board |
| NER | Net enrolment ratio |
| NIC | network interface card |
| NGO | Non-governmental organisation |
| NW | North West |
| NC | Northern Cape |
| Ntsika/DTI | Ntsika Enterprise Promotion Agency/Department of Trade and Industry |
| ODP | Open Directory Project |
| OSS | operations support system |
| OECD | Organisation for Economic Co-operation and Development |
| OPM | Other People's Money |
| OPR | Other People's Resources |
| PT | Part Time |
| PPC | Pay Per Click (a search engine advertising model) |
| P2P | Peer to Peer (as in music file sharing systems like KaZaA) |
| PCs | Personal computers |
| PHP | Personal Home Page (original name for PHP scripting language) |
| PERSAL | Personnel salary system |
| POP | Point of Purchase |
| POS | point of sale |
| POP3 | Post Office Protocol, Version 3 |
| PG | Postgraduate |
| PM | Preventive Management |
| PE | Printer Error (a publishing term) |
| PLR | Private Label Rights |
| PMB | Private Message Board |
| PLM | product lifecycle management |
| PL | Profit and Loss |
| PSLSD | Project for Statistics on Living Standards and Development |
| PPM | Project portfolio management |
| PFMA | Public Finance Management Act |
| PO | Purchase Order |